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Familial male-limited precocious puberty : ウィキペディア英語版 | Familial male-limited precocious puberty
Familial male-limited precocious puberty, often abbreciated as FMPP, also known as familial sexual precocity or gonadotropin-independent testotoxicosis, is a form of gonadotropin-independent precocious puberty in which boys experience early onset and progression of puberty. Signs of puberty can develop as early as an age of 1 year. The spinal length in boys may be short due to a rapid advance in epiphyseal maturation. It is an autosomal dominant〔 condition with a mutation of the luteinizing hormone (LH) receptor. Treatment is with drugs that suppress gonadal steroidogenesis, such as cyproterone acetate, ketoconazole, spironolactone, and testolactone. Alternatively, the combination of the androgen receptor antagonist bicalutamide and the aromatase inhibitor anastrozole may be used. ==See also==
* Hypergonadism, hyperandrogenism, and precocious puberty * Leydig cell hypoplasia (or LH insensitivity) * Follicle-stimulating hormone insensitivity * Gonadotropin-releasing hormone insensitivity * Inborn errors of steroid metabolism
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